Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs.
نویسندگان
چکیده
An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 50 61 شماره
صفحات -
تاریخ انتشار 2014